Ante-mortem blood (cardiac), gastric aspirate, urine. Collected at post-mortem, Friday 09:35 AM.

Substance	Matrix	Concentration	Reference Range
Alprazolam	Blood	0.8 mg/L	Therapeutic: 0.01–0.10 mg/L · Toxic: >0.20 mg/L
Ethanol	Blood	0.04%	Legal limit: 0.08%
Caffeine	Blood	Trace	Consistent with coffee consumption
Ibuprofen	Blood	Trace	Consistent with prior week ingestion
Other controlled substances	All matrices	None detected	—

Alprazolam is a Schedule IV benzodiazepine with a plasma half-life of 6–12 hours. At 0.8 mg/L in combination with 0.04% BAC, clinically expected effects include: severe sedation, ataxia, impaired motor coordination, anterograde amnesia, and markedly reduced capacity for volitional physical action. Peak serum concentration is typically reached 1–2 hours post-oral ingestion. Gastric aspirate analysis confirmed oral ingestion. No tablet fragments were recovered. The compound had been dissolved in liquid prior to ingestion. Using standard pharmacokinetic back-calculation (death time 23:10 ± 10 min, half-life midpoint 9 hours, peak conc. window 1–2 hrs):

Parameter	Value
Estimated time of death	23:10 ± 10 min (from post-mortem report)
Back-calculated ingestion window (peak)	20:30 – 22:30 (Thursday)
Margin of error	± 30 minutes

The Alprazolam concentration documented in this case substantially exceeds the therapeutic range. Dissolution of the compound in a liquid prior to ingestion is confirmed by gastric analysis. I am not in a position to determine whether ingestion was voluntary or involuntary — that determination falls outside the scope of this report.